molecular options as drug targets and antibody-drug conjugates for remedy

September 25, 2020
Antibodies, Assay Kits, Biology Cells, cDNA, Clia Kits, Culture Cells, Devices, DNA, DNA Templates, DNA Testing, Elisa Kits, Enzymes, Equipments, Exosomes, Gels, Isotypes, Medium & Serums, NATtrol, Panel, Particles, PCR, Pcr Kits, Peptides, Reagents, Recombinant Proteins, Ria Kits, RNA, Vector & Virus, Western Blot

MET and RON receptor tyrosine kinases in colorectal adenocarcinoma: molecular options as drug targets and antibody-drug conjugates for remedy

 

Superior colorectal adenocarcinoma (CRAC), featured by distinctive histopathological look, distant organ metastasis, acquired chemoresistance, and tumorigenic stemness is a bunch of heterogeneous cancers with distinctive genetic signatures and malignant phenotypes. Therapy of CRAC is a frightening activity for oncologists.

 

At the moment, numerous methods together with molecular focusing on utilizing therapeutic monoclonal antibodies, small molecule kinase inhibitors and immunoregulatory checkpoint remedy have been utilized to fight this lethal illness. Nevertheless, these therapeutic modalities and approaches obtain solely restricted success. Thus, there’s a pharmaceutical want to find new targets and develop novel therapeutics for CRAC remedy. MET and RON receptor tyrosine kinases have been implicated in CRAC pathogenesis.

 

Scientific research have revealed that aberrant MET and/or RON expression and signaling are essential in regulating CRAC development and malignant phenotypes. Elevated MET and/or RON expression additionally has prognostic worth for CRAC development and affected person survival.

 

These options present the rationale to focus on MET and RON for scientific CRAC intervention. At current, using small molecule kinase inhibitors focusing on MET for CRAC therapy has achieved vital progress with a number of approvals for scientific utility.

 

Nonetheless, antibody-based biotherapeutics, though beneath scientific trials for greater than Eight years, have made little or no progress. On this assessment, we focus on the significance of MET and/or RON in CRAC tumorigenesis and growth of anti-MET, anti-RON, and MET and RON-dual focusing on antibody-drug conjugates for scientific utility. The findings from each preclinical research and scientific trials spotlight the potential of this novel kind of biotherapeutics for CRAC remedy sooner or later.

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Anti-Natriuretic Peptide Receptor C (NPR3) Mouse Monoclonal Antibody [Clone ID: OTI11B6]
M03589-3 100ul
EUR 523
Description: Boster Bio Anti-NPR3 (Natriuretic Peptide Receptor C) mouse monoclonal antibody, clone OTI11B6 (formerly 11B6). Catalog# M03589-3. Tested in FC, IF, IHC, WB. This antibody reacts with Human, Mouse, Rat.

Vimentin mouse monoclonal Antibody [AFBlocking Peptide
MBS9620312-1mg 1mg
EUR 380

Vimentin mouse monoclonal Antibody [AFBlocking Peptide
MBS9620312-5x1mg 5x1mg
EUR 1650

Natriuretic Peptide Receptor C (NPR3) Mouse Monoclonal Antibody [Clone:2C2]
E45M09579 100 ug
EUR 595

Natriuretic Peptide Receptor C (NPR3) Mouse Monoclonal Antibody [Clone 2C2]
E45M09579V-2 50 ul
EUR 195

Natriuretic Peptide Receptor C (NPR3) Mouse Monoclonal Antibody [Clone:2G2]
E45M09580 100 ug
EUR 595

Natriuretic Peptide Receptor C (NPR3) Mouse Monoclonal Antibody [Clone 2G2]
E45M09580V-2 50 ul
EUR 195

Natriuretic Peptide Receptor C (NPR3) Mouse Monoclonal Antibody [Clone:4C3]
E45M09642 100 ug
EUR 595

Natriuretic Peptide Receptor C (NPR3) Mouse Monoclonal Antibody [Clone 4C3]
E45M09642V-2 50 ul
EUR 195

Natriuretic Peptide Receptor C (NPR3) Mouse Monoclonal Antibody [Clone:4H1]
E45M09664 100 ug
EUR 595

Natriuretic Peptide Receptor C (NPR3) Mouse Monoclonal Antibody [Clone 4H1]
E45M09664V-2 50 ul
EUR 195

Natriuretic Peptide Receptor C (NPR3) Mouse Monoclonal Antibody [Clone 4A1]
E45M09666V-2 50 ul
EUR 195

Anti-Gastric Inhibitory Peptide (3-42)(GIP (3-42)) Mouse monoclonal antibody
ABS-054-14-04 400µl
EUR 1530.66
Description: Mouse

Anti-Gastric Inhibitory Peptide (3-42)(GIP (3-42)) Mouse monoclonal antibody
ABS-054-14-1 1ml
EUR 3417.43
Description: Mouse

Anti-Gastric Inhibitory Peptide (3-42) (GIP (3-42)) Mouse monoclonal antibody
ABS-057-25-04 400µl
EUR 1530.66
Description: Mouse

Anti-Gastric Inhibitory Peptide (3-42) (GIP (3-42)) Mouse monoclonal antibody
ABS-057-25-1 1ml
EUR 3417.43
Description: Mouse

Anti-Gastric Inhibitory Peptide (GIP) Mouse monoclonal antibody, biotinylated
ABS-054-24B-015 150µl
EUR 1730.58
Description: Mouse

Natriuretic Peptide Receptor C (NPR3) Mouse Monoclonal Antibody [Clone:2B12]
E45M09665 100 ug
EUR 595

Natriuretic Peptide Receptor C (NPR3) Mouse Monoclonal Antibody [Clone 2B12]
E45M09665V-2 50 ul
EUR 195

Natriuretic Peptide Receptor C (NPR3) Mouse Monoclonal Antibody [Clone 11A6]
E45M09696V-2 50 ul
EUR 195

Natriuretic Peptide Receptor C (NPR3) Mouse Monoclonal Antibody [Clone 11B6]
E45M09697V-2 50 ul
EUR 195

Natriuretic Peptide Receptor C (NPR3) Mouse Monoclonal Antibody [Clone 11H5]
E45M09698V-2 50 ul
EUR 195

Natriuretic Peptide Receptor C (NPR3) Mouse Monoclonal Antibody [Clone:11B5]
E45M09699 100 ug
EUR 595

Natriuretic Peptide Receptor C (NPR3) Mouse Monoclonal Antibody [Clone 11B5]
E45M09699V-2 50 ul
EUR 195

Natriuretic Peptide Receptor C (NPR3) Mouse Monoclonal Antibody [Clone:11H6]
E45M09700 100 ug
EUR 595

Natriuretic Peptide Receptor C (NPR3) Mouse Monoclonal Antibody [Clone 11H6]
E45M09700V-2 50 ul
EUR 195

Mouse monoclonal Anti-HA-tag peptide IgG
AB-10110 100 ug
EUR 562.8

Anti-NPR3 (Natriuretic Peptide Receptor C) mouse monoclonal antibody, clone OTI2C2 (formerly 2C2)
TA500955 100 µl Ask for price

Anti-NPR3 (Natriuretic Peptide Receptor C) mouse monoclonal antibody, clone OTI2C2 (formerly 2C2)
TA500955S 30 µl Ask for price

Anti-NPR3 (Natriuretic Peptide Receptor C) mouse monoclonal antibody, clone OTI2G2 (formerly 2G2)
TA500956 100 µl Ask for price

Anti-NPR3 (Natriuretic Peptide Receptor C) mouse monoclonal antibody, clone OTI2G2 (formerly 2G2)
TA500956S 30 µl Ask for price

Anti-NPR3 (Natriuretic Peptide Receptor C) mouse monoclonal antibody, clone OTI4C3 (formerly 4C3)
TA501021 100 µl Ask for price

Anti-NPR3 (Natriuretic Peptide Receptor C) mouse monoclonal antibody, clone OTI4C3 (formerly 4C3)
TA501021S 30 µl Ask for price

Anti-NPR3 (Natriuretic Peptide Receptor C) mouse monoclonal antibody, clone OTI4H1 (formerly 4H1)
TA501044 100 µl Ask for price

Anti-NPR3 (Natriuretic Peptide Receptor C) mouse monoclonal antibody, clone OTI4H1 (formerly 4H1)
TA501044S 30 µl Ask for price

Anti-NPR3 (Natriuretic Peptide Receptor C) mouse monoclonal antibody, clone OTI2B12 (formerly 2B12)
TA501045 100 µl Ask for price

Anti-NPR3 (Natriuretic Peptide Receptor C) mouse monoclonal antibody, clone OTI2B12 (formerly 2B12)
TA501045S 30 µl Ask for price

Anti-NPR3 (Natriuretic Peptide Receptor C) mouse monoclonal antibody, clone OTI4A1 (formerly 4A1)
TA501046 100 µl Ask for price

Anti-NPR3 (Natriuretic Peptide Receptor C) mouse monoclonal antibody, clone OTI4A1 (formerly 4A1)
TA501046S 30 µl Ask for price

Anti-NPR3 (Natriuretic Peptide Receptor C) mouse monoclonal antibody, clone OTI11A6 (formerly 11A6)
TA501076 100 µl Ask for price

Anti-NPR3 (Natriuretic Peptide Receptor C) mouse monoclonal antibody, clone OTI11A6 (formerly 11A6)
TA501076S 30 µl Ask for price

Anti-NPR3 (Natriuretic Peptide Receptor C) mouse monoclonal antibody, clone OTI11B6 (formerly 11B6)
TA501077 100 µl Ask for price

Anti-NPR3 (Natriuretic Peptide Receptor C) mouse monoclonal antibody, clone OTI11B6 (formerly 11B6)
TA501077S 30 µl Ask for price

Anti-NPR3 (Natriuretic Peptide Receptor C) mouse monoclonal antibody, clone OTI11H5 (formerly 11H5)
TA501078 100 µl Ask for price

Anti-NPR3 (Natriuretic Peptide Receptor C) mouse monoclonal antibody, clone OTI11H5 (formerly 11H5)
TA501078S 30 µl Ask for price

Anti-NPR3 (Natriuretic Peptide Receptor C) mouse monoclonal antibody, clone OTI11B5 (formerly 11B5)
TA501079 100 µl Ask for price

Anti-NPR3 (Natriuretic Peptide Receptor C) mouse monoclonal antibody, clone OTI11B5 (formerly 11B5)
TA501079S 30 µl Ask for price

Anti-NPR3 (Natriuretic Peptide Receptor C) mouse monoclonal antibody, clone OTI11H6 (formerly 11H6)
TA501080 100 µl Ask for price

Anti-NPR3 (Natriuretic Peptide Receptor C) mouse monoclonal antibody, clone OTI11H6 (formerly 11H6)
TA501080S 30 µl Ask for price

Mouse Monoclonal anti-human Orexin-B peptide
hAP-0501 100ug
EUR 250

Mouse Monoclonal anti-human Phosphotyrosine peptide
hAP-0637 100ug
EUR 250

Anti-Gastric Inhibitory Peptide (3-42)(GIP (3-42)) Mouse monoclonal antibody, biotinylated
ABS-054-14B-015 150µl
EUR 1730.58
Description: Mouse

Natriuretic Peptide Precursor B (NPPB) Monoclonal Antibody (Mouse)
4-MAA503Mu21
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Description: A Rat monoclonal antibody against Mouse Natriuretic Peptide Precursor B (NPPB)

Anti-Natriuretic Peptide Receptor A (NPR1) Mouse Monoclonal Antibody [Clone ID: OTI7H7]
M01042 100ul
EUR 523
Description: Boster Bio NPR1 mouse monoclonal antibody, clone OTI7H7 (formerly 7H7). Catalog# M01042. Tested in WB. This antibody reacts with Human, Mouse, Rat.

Monoclonal Anti-Cytokeratin Peptide 7 Antibody Antibody
GWB-BBB023 0.1 mg Ask for price

Monoclonal Anti-Cytokeratin Peptide 18 Antibody Antibody
GWB-BBB025 0.1 mg Ask for price

Natriuretic Peptide Precursor B (NPPB) Monoclonal Antibody (Mouse), APC
4-MAA503Mu21-APC
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Description: A Rat monoclonal antibody against Mouse Natriuretic Peptide Precursor B (NPPB). This antibody is labeled with APC.

Natriuretic Peptide Precursor B (NPPB) Monoclonal Antibody (Mouse), Cy3
4-MAA503Mu21-Cy3
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Description: A Rat monoclonal antibody against Mouse Natriuretic Peptide Precursor B (NPPB). This antibody is labeled with Cy3.

Natriuretic Peptide Precursor B (NPPB) Monoclonal Antibody (Mouse), HRP
4-MAA503Mu21-HRP
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Description: A Rat monoclonal antibody against Mouse Natriuretic Peptide Precursor B (NPPB). This antibody is labeled with HRP.

Natriuretic Peptide Precursor B (NPPB) Monoclonal Antibody (Mouse), PE
4-MAA503Mu21-PE
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Description: A Rat monoclonal antibody against Mouse Natriuretic Peptide Precursor B (NPPB). This antibody is labeled with PE.

C-Peptide (CP) Monoclonal Antibody
CAU29243-100ul 100ul
EUR 267.8

C-Peptide (CP) Monoclonal Antibody
CAU29243-200ul 200ul
EUR 334.3

C-Peptide (CP) Monoclonal Antibody
CAU30193-100ul 100ul
EUR 254.4

C-Peptide (CP) Monoclonal Antibody
CAU30193-200ul 200ul
EUR 317.5

C-Peptide (CP) Monoclonal Antibody
CAU30505-100ul 100ul
EUR 247.7

C-Peptide (CP) Monoclonal Antibody
CAU30505-200ul 200ul
EUR 309.1

C-Peptide (CP) Monoclonal Antibody
CAU30630-100ul 100ul
EUR 245.8

C-Peptide (CP) Monoclonal Antibody
CAU30630-200ul 200ul
EUR 306.6

C-Peptide (CP) Monoclonal Antibody
MBS2105042-INQUIRE INQUIRE Ask for price

Natriuretic Peptide Precursor B (NPPB) Monoclonal Antibody (Mouse), FITC
4-MAA503Mu21-FITC
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  • 20ul
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Description: A Rat monoclonal antibody against Mouse Natriuretic Peptide Precursor B (NPPB). This antibody is labeled with FITC.

Natriuretic Peptide Receptor A (NPR1) Mouse Monoclonal Antibody [Clone:7H7]
E45M17001 100 ug
EUR 595

Natriuretic Peptide Receptor A (NPR1) Mouse Monoclonal Antibody [Clone 7H7]
E45M17001V-2 50 ul
EUR 195

C-Type Natriuretic Peptide (CNP) Monoclonal Antibody
CAU30663-100ul 100ul
EUR 225.6

C-Type Natriuretic Peptide (CNP) Monoclonal Antibody
CAU30663-200ul 200ul
EUR 282.2

Anti-Cytokeratin Peptide 7 antibody (monoclonal)
MBS175076-01mg 0.1mg
EUR 450

Anti-Cytokeratin Peptide 7 antibody (monoclonal)
MBS175076-5x01mg 5x0.1mg
EUR 1870

Anti-Cytokeratin Peptide 18 antibody (monoclonal)
MBS175098-01mg 0.1mg
EUR 450

Anti-Cytokeratin Peptide 18 antibody (monoclonal)
MBS175098-5x01mg 5x0.1mg
EUR 1870

Mouse anti- Human Natriuretic peptides B(NPPB) monoclonal Antibody
MBS1494887-005mg 0.05mg
EUR 220

Mouse anti- Human Natriuretic peptides B(NPPB) monoclonal Antibody
MBS1494887-01mg 0.1mg
EUR 300

Mouse anti- Human Natriuretic peptides B(NPPB) monoclonal Antibody
MBS1494887-5x01mg 5x0.1mg
EUR 1350

Mouse Monoclonal Anti-Mouse/rat NOS-II/i-NOS peptide, ascites
INOS23-M 100 ul
EUR 578.4

Natriuretic Peptides B Mouse Monoclonal Antibody
E10G20491 100 μl
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

Natriuretic Peptides B Mouse Monoclonal Antibody
E10G20492 100 μl
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

Natriuretic Peptides B Mouse Monoclonal Antibody
E10G20493 100 μl
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

Natriuretic Peptide Precursor B (NPPB) Monoclonal Antibody (Mouse), APC-Cy7
4-MAA503Mu21-APC-Cy7
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Description: A Rat monoclonal antibody against Mouse Natriuretic Peptide Precursor B (NPPB). This antibody is labeled with APC-Cy7.

Monoclonal Antibody to C-Type Natriuretic Peptide (CNP)
MAA721Hu22 100ul
EUR 235

Monoclonal Antibody to C-Type Natriuretic Peptide (CNP)
MBS2111573-INQUIRE INQUIRE Ask for price

Natriuretic Peptide Precursor B (NPPB) Monoclonal Antibody (Mouse), Biotinylated
4-MAA503Mu21-Biotin
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Description: A Rat monoclonal antibody against Mouse Natriuretic Peptide Precursor B (NPPB). This antibody is labeled with Biotin.

Monoclonal Antibody to C-Peptide (CP)
MAA447Po21 100ul
EUR 279

Monoclonal Antibody to C-Peptide (CP)
MAA447Ra21 100ul
EUR 258

Monoclonal Antibody to C-Peptide (CP)
MAA447Ra22 100ul
EUR 256

Monoclonal Antibody to C-Peptide (CP)
MAA447Ra23 100ul
EUR 264

Monoclonal Antibody to C-Peptide (CP)
MAA447Ra24 100ul
EUR 264

Monoclonal Antibody to C-Peptide (CP)
MAA447Ra28 100ul
EUR 265

Monoclonal Antibody to C-Peptide (CP)
MBS2111139-INQUIRE INQUIRE Ask for price

Monoclonal Antibody to C-Peptide (CP)
MBS2111140-INQUIRE INQUIRE Ask for price

Monoclonal Antibody to C-Peptide (CP)
MBS2025818-INQUIRE INQUIRE Ask for price

Natriuretic Peptide Receptor B (NPR2) mouse monoclonal antibody, clone 1E4, Purified
AM31118PU-N 50 µg Ask for price

Monoclonal mouse anti-human brain natriuretic peptide (BNP)
MBS660237-10mg 10mg
EUR 6785

Monoclonal mouse anti-human brain natriuretic peptide (BNP)
MBS660237-15mg 15mg
EUR 9610

Monoclonal mouse anti-human brain natriuretic peptide (BNP)
MBS660237-1mg 1mg
EUR 900

Monoclonal mouse anti-human brain natriuretic peptide (BNP)
MBS660237-25mg 25mg
EUR 15015

Monoclonal mouse anti-human brain natriuretic peptide (BNP)
MBS660237-5mg 5mg
EUR 3670

C-Peptide (CP) Monoclonal Antibody (Rat)
4-MAA447Ra21
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  • 20ul
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Description: A Mouse monoclonal antibody against Rat C-Peptide (CP)

C-Peptide (CP) Monoclonal Antibody (Rat)
4-MAA447Ra28
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Description: A Mouse monoclonal antibody against Rat C-Peptide (CP)

C-Peptide (CP) Monoclonal Antibody (Human)
4-MAA447Po21
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Description: A Mouse monoclonal antibody against Human C-Peptide (CP)

Mouse monoclonal anti-human Proteolipid protein peptide 139-151 IgG, aff pure
PLP139-M 100 ug
EUR 578.4

Anti-Natriuretic Peptide A Rabbit Rabbit Monoclonal Antibody
2356-100uL 100 μL
EUR 329

Anti-Natriuretic Peptide A Rabbit Rabbit Monoclonal Antibody
2356-20uL 20 μL
EUR 129

Natriuretic Peptide Receptor B (NPR2) (131-231) mouse monoclonal antibody, clone 2A6, Purified
AM31133PU-N 50 µg Ask for price

Anti-Cytokeratin Peptide 18 Antibody ( Monoclonal, CY-90)
Ab1037 100μ/Vial
EUR 0.1

Anti-Cytokerain Peptide 7 Antibody (Monoclonal,LDS-68)
Ab1041 100μ/Vial
EUR 0.1

Monoclonal RXRB Antibody (Hinge Peptide)
AMM02172G 0.05ml
EUR 580.8
Description: A Monoclonal antibody against Human RXRB (Hinge Peptide). The antibodies are raised in Mouse. This antibody is applicable in WB and IHC-P

Mouse Monoclonal Anti-Human Human Ki67 (Proliferation Marker) peptide IgG
KI672-M 100 ul
EUR 578.4

C-Peptide (CP) Monoclonal Antibody (Rat), PE
4-MAA447Ra21-PE
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Description: A Mouse monoclonal antibody against Rat C-Peptide (CP). This antibody is labeled with PE.

C-Peptide (CP) Monoclonal Antibody (Rat), PE
4-MAA447Ra28-PE
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  • 20ul
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Description: A Mouse monoclonal antibody against Rat C-Peptide (CP). This antibody is labeled with PE.

C-Peptide (CP) Monoclonal Antibody (Rat), APC
4-MAA447Ra21-APC
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  • 20ul
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Description: A Mouse monoclonal antibody against Rat C-Peptide (CP). This antibody is labeled with APC.

C-Peptide (CP) Monoclonal Antibody (Rat), Cy3
4-MAA447Ra21-Cy3
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  • 20ul
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Description: A Mouse monoclonal antibody against Rat C-Peptide (CP). This antibody is labeled with Cy3.

C-Peptide (CP) Monoclonal Antibody (Rat), HRP
4-MAA447Ra21-HRP
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  • 20ul
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Description: A Mouse monoclonal antibody against Rat C-Peptide (CP). This antibody is labeled with HRP.

C-Peptide (CP) Monoclonal Antibody (Rat), APC
4-MAA447Ra28-APC
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  • 20ul
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Description: A Mouse monoclonal antibody against Rat C-Peptide (CP). This antibody is labeled with APC.

C-Peptide (CP) Monoclonal Antibody (Rat), Cy3
4-MAA447Ra28-Cy3
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  • 20ul
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Description: A Mouse monoclonal antibody against Rat C-Peptide (CP). This antibody is labeled with Cy3.

C-Peptide (CP) Monoclonal Antibody (Rat), HRP
4-MAA447Ra28-HRP
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Description: A Mouse monoclonal antibody against Rat C-Peptide (CP). This antibody is labeled with HRP.

Monoclonal Anti-Human/mouse/rat Insulin chain B peptide IgG, aff pure
INSB22-M 100 ul
EUR 578.4

C-Peptide (CP) Monoclonal Antibody (Human), PE
4-MAA447Po21-PE
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Description: A Mouse monoclonal antibody against Human C-Peptide (CP). This antibody is labeled with PE.

C-Peptide (CP) Monoclonal Antibody (Rat), FITC
4-MAA447Ra21-FITC
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  • 20ul
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Description: A Mouse monoclonal antibody against Rat C-Peptide (CP). This antibody is labeled with FITC.

C-Peptide (CP) Monoclonal Antibody (Rat), FITC
4-MAA447Ra28-FITC
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  • 20ul
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Description: A Mouse monoclonal antibody against Rat C-Peptide (CP). This antibody is labeled with FITC.

C-Peptide (CP) Monoclonal Antibody (Human), APC
4-MAA447Po21-APC
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  • 20ul
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  • 10ml
Description: A Mouse monoclonal antibody against Human C-Peptide (CP). This antibody is labeled with APC.

C-Peptide (CP) Monoclonal Antibody (Human), Cy3
4-MAA447Po21-Cy3
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Description: A Mouse monoclonal antibody against Human C-Peptide (CP). This antibody is labeled with Cy3.

C-Peptide (CP) Monoclonal Antibody (Human), HRP
4-MAA447Po21-HRP
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Description: A Mouse monoclonal antibody against Human C-Peptide (CP). This antibody is labeled with HRP.

PE-Linked Monoclonal Antibody to C-Type Natriuretic Peptide (CNP)
MBS2118361-INQUIRE INQUIRE Ask for price

C-Peptide (CP) Monoclonal Antibody (Human), FITC
4-MAA447Po21-FITC
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Description: A Mouse monoclonal antibody against Human C-Peptide (CP). This antibody is labeled with FITC.

Monoclonal mouse anti-human brain natriuretic peptide (BNP), in vitro
MBS660305-10mg 10mg
EUR 5145

Monoclonal mouse anti-human brain natriuretic peptide (BNP), in vitro
MBS660305-15mg 15mg
EUR 7215

Monoclonal mouse anti-human brain natriuretic peptide (BNP), in vitro
MBS660305-1mg 1mg
EUR 710

Monoclonal mouse anti-human brain natriuretic peptide (BNP), in vitro
MBS660305-25mg 25mg
EUR 11365

Monoclonal mouse anti-human brain natriuretic peptide (BNP), in vitro
MBS660305-5mg 5mg
EUR 2755

Mouse monoclonal C-peptide antibody
MBS5305826-1mg 1mg
EUR 975

Mouse monoclonal C-peptide antibody
MBS5305826-5x1mg 5x1mg
EUR 4240

Mouse monoclonal C-peptide antibody
MBS5305827-1mg 1mg
EUR 975

Mouse monoclonal C-peptide antibody
MBS5305827-5x1mg 5x1mg
EUR 4240

Mouse monoclonal C-peptide antibody
MBS5305828-1mg 1mg
EUR 975

Mouse monoclonal C-peptide antibody
MBS5305828-5x1mg 5x1mg
EUR 4240

APC-Linked Monoclonal Antibody to C-Type Natriuretic Peptide (CNP)
MBS2119705-INQUIRE INQUIRE Ask for price

Cy3-Linked Monoclonal Antibody to C-Type Natriuretic Peptide (CNP)
MBS2121192-INQUIRE INQUIRE Ask for price

HRP-Linked Monoclonal Antibody to C-Type Natriuretic Peptide (CNP)
MBS2115673-INQUIRE INQUIRE Ask for price

Brain Natriuretic Peptide (BNP) Monoclonal Antibody
CAU29254-100ul 100ul
EUR 201.6

Brain Natriuretic Peptide (BNP) Monoclonal Antibody
CAU29254-200ul 200ul
EUR 252

Brain Natriuretic Peptide (BNP) Monoclonal Antibody
CAU29496-100ul 100ul
EUR 236.2

Brain Natriuretic Peptide (BNP) Monoclonal Antibody
CAU29496-200ul 200ul
EUR 295.7

Brain Natriuretic Peptide (BNP) Monoclonal Antibody
CAU29531-100ul 100ul
EUR 215

Brain Natriuretic Peptide (BNP) Monoclonal Antibody
CAU29531-200ul 200ul
EUR 268.8

Brain Natriuretic Peptide (BNP) Monoclonal Antibody
CAU30640-100ul 100ul
EUR 215

Brain Natriuretic Peptide (BNP) Monoclonal Antibody
CAU30640-200ul 200ul
EUR 268.8

Monoclonal Natriuretic Peptide Receptor C Antibody, Clone: 1748CT403.18.42
AMM02573G 0.1ml
EUR 580.8
Description: A Monoclonal antibody against Human Natriuretic Peptide Receptor C. The antibodies are raised in Mouse and are from clone 1748CT403.18.42. This antibody is applicable in WB, E

FITC-Linked Monoclonal Antibody to C-Type Natriuretic Peptide (CNP)
MBS2114346-INQUIRE INQUIRE Ask for price

Monoclonal Antibody to Amyloid Beta Peptide 142 (Ab142)
MBS2138814-INQUIRE INQUIRE Ask for price

Biotin-Linked Monoclonal Antibody to C-Type Natriuretic Peptide (CNP)
MBS2112771-INQUIRE INQUIRE Ask for price

C-Peptide (CP) Monoclonal Antibody (Rat), Biotinylated
4-MAA447Ra21-Biotin
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  • 20ul
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Description: A Mouse monoclonal antibody against Rat C-Peptide (CP). This antibody is labeled with Biotin.

C-Peptide (CP) Monoclonal Antibody (Rat), Biotinylated
4-MAA447Ra28-Biotin
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Description: A Mouse monoclonal antibody against Rat C-Peptide (CP). This antibody is labeled with Biotin.

 

 

 

Antibody Response to Canine Parvovirus Vaccination in Canines with Hyperadrenocorticism Handled with Trilostane

 

  • It’s unknown how canines with hyperadrenocorticism (HAC) reply to vaccination. This research measured antibodies in opposition to canine parvovirus (CPV) in canines with HAC handled with trilostane earlier than and after CPV vaccination, and in contrast the immune response to that from wholesome canines. Eleven canines with HAC, and wholesome age-matched management canines (n = 31) obtained a modified-live CPV vaccine. Antibodies have been decided on days 0, 7, and 28 by hemagglutination inhibition. Univariate evaluation was used to match the immune response of canines with HAC and wholesome canines.

 

  • Pre-vaccination antibodies (≥10) have been detected in 100% of canines with HAC (11/11; 95% CI: 70.0-100) and in 93.5% of wholesome canines (29/31; 95% CI: 78.3-99.2). No ≥4-fold enhance in antibody titer was noticed in canines with HAC whereas in 22.6% of wholesome canines, a ≥4-fold titer enhance was noticed (7/31; 95% CI: 11.1-40.1).

 

  • Gentle vaccine-associated antagonistic occasions (VAAEs) have been detected in 54.5% of canines with HAC (6/11; 95% CI: 28.0-78.8) and in 29.0% of wholesome canines (9/31; 95% CI: 15.9-46.8). There was neither a vital distinction in presence of pre-vaccination antibodies (p = 1.000), or response to vaccination (p = 0.161), nor within the prevalence of VAAEs (p = 0.158). Immune perform of canines with HAC handled with trilostane appears similar to that of wholesome canines.

 

Design and Validation of Linkers for Website-Particular Preparation of Antibody-Drug Conjugates Carrying A number of Drug Copies Per Cysteine Conjugation Website

 

First-generation cysteine-based site-specific antibody-drug conjugates (ADCs) are restricted to 1 drug per cysteine. Nevertheless, sure purposes require a excessive drug to antibody ratio (DAR), corresponding to when low-potency payloads are used. Increased drug load may be achieved utilizing classical cysteine conjugation strategies, however these lead to heterogeneity, suboptimal efficacy and pharmacokinetics.

 

Right here, we describe the design, synthesis and validation of heterobifunctional linkers that can be utilized for the preparation of ADCs with a DAR of two, three and 4 in a site-specific method per single cysteine conjugation website, leading to site-specific ADCs with a DAR of 4, six and eight. The designed linkers carry a sulfhydryl-specific iodoacetyl reactive group, and a number of cyclic diene moieties which might effectively react with maleimide-carrying payloads via the Diels-Alder response.

 

As a proof of idea, we synthesized site-specific DAR 4, six and eight ADCs carrying tubulysin (AZ13601508) utilizing engineered antibodies with a cysteine inserted after place 239 within the antibody CH2 area.

 

We evaluated and in contrast the in vitro cytotoxicity of ADCs obtained by way of the site-specific platform described herein, with ADCs ready utilizing classical cysteine conjugation. Our knowledge validated a novel cysteine-based conjugation platform for the preparation of site-specific ADCs with excessive drug load for therapeutic purposes.

 

Mouse Monoclonal Calcitonin antibody
MBS5305329-5x025mg 5x0.25mg
EUR 1350

Mouse Monoclonal Calcitonin antibody
MBS5305330-025mg 0.25mg
EUR 335

Mouse Monoclonal Calcitonin antibody
MBS5305330-5x025mg 5x0.25mg
EUR 1350

Mouse Monoclonal Calcitonin antibody
MBS5305331-025mg 0.25mg
EUR 415

Mouse Monoclonal Calcitonin antibody
MBS5305331-5x025mg 5x0.25mg
EUR 1705

Mouse Monoclonal Calcitonin antibody
MBS5305332-05mg 0.5mg
EUR 595

Mouse Monoclonal Calcitonin antibody
MBS5305332-5x05mg 5x0.5mg
EUR 2525

Mouse Monoclonal Calcitonin antibody
MBS5305333-05mg 0.5mg
EUR 595

Mouse Monoclonal Calcitonin antibody
MBS5305333-5x05mg 5x0.5mg
EUR 2525

Monoclonal Antibody to Calcitonin (CT)
MAA472Ra21 100ul
EUR 253

Monoclonal Antibody to Calcitonin (CT)
MBS2090546-INQUIRE INQUIRE Ask for price

Monoclonal Antibody to Calcitonin (CT)
MBS2085844-INQUIRE INQUIRE Ask for price

Calcitonin (CT) Monoclonal Antibody (Rat)
4-MAA472Ra21
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Description: A Mouse monoclonal antibody against Rat Calcitonin (CT)

Anti-Human Calcitonin (ABT124) Mouse Monoclonal Antibody
MBS9511079-005mL 0.05mL
EUR 190

Anti-Human Calcitonin (ABT124) Mouse Monoclonal Antibody
MBS9511079-01mL 0.1mL
EUR 255

Anti-Human Calcitonin (ABT124) Mouse Monoclonal Antibody
MBS9511079-02mL 0.2mL
EUR 325

Anti-Human Calcitonin (ABT124) Mouse Monoclonal Antibody
MBS9511079-1mL 1mL
EUR 580

Anti-Human Calcitonin (ABT124) Mouse Monoclonal Antibody
MBS9511079-5x1mL 5x1mL
EUR 2455

Anti-Human Calcitonin (ABT285) Mouse Monoclonal Antibody
MBS9511080-005mL 0.05mL
EUR 190

Anti-Human Calcitonin (ABT285) Mouse Monoclonal Antibody
MBS9511080-01mL 0.1mL
EUR 255

Anti-Human Calcitonin (ABT285) Mouse Monoclonal Antibody
MBS9511080-02mL 0.2mL
EUR 325

Anti-Human Calcitonin (ABT285) Mouse Monoclonal Antibody
MBS9511080-1mL 1mL
EUR 580

Anti-Human Calcitonin (ABT285) Mouse Monoclonal Antibody
MBS9511080-5x1mL 5x1mL
EUR 2455

Anti-Human Calcitonin (ABT385) Mouse Monoclonal Antibody
MBS9511081-005mL 0.05mL
EUR 190

Anti-Human Calcitonin (ABT385) Mouse Monoclonal Antibody
MBS9511081-01mL 0.1mL
EUR 255

Anti-Human Calcitonin (ABT385) Mouse Monoclonal Antibody
MBS9511081-02mL 0.2mL
EUR 325

Anti-Human Calcitonin (ABT385) Mouse Monoclonal Antibody
MBS9511081-1mL 1mL
EUR 580

Anti-Human Calcitonin (ABT385) Mouse Monoclonal Antibody
MBS9511081-5x1mL 5x1mL
EUR 2455

Anti-Human Calcitonin (ABT389) Mouse Monoclonal Antibody
MBS9511082-005mL 0.05mL
EUR 190

Anti-Human Calcitonin (ABT389) Mouse Monoclonal Antibody
MBS9511082-01mL 0.1mL
EUR 255

Anti-Human Calcitonin (ABT389) Mouse Monoclonal Antibody
MBS9511082-02mL 0.2mL
EUR 325

Anti-Human Calcitonin (ABT389) Mouse Monoclonal Antibody
MBS9511082-1mL 1mL
EUR 580

Anti-Human Calcitonin (ABT389) Mouse Monoclonal Antibody
MBS9511082-5x1mL 5x1mL
EUR 2455

Anti-Human Calcitonin (ABT403) Mouse Monoclonal Antibody
MBS9511083-005mL 0.05mL
EUR 190

Anti-Human Calcitonin (ABT403) Mouse Monoclonal Antibody
MBS9511083-01mL 0.1mL
EUR 255

Anti-Human Calcitonin (ABT403) Mouse Monoclonal Antibody
MBS9511083-02mL 0.2mL
EUR 325

Anti-Human Calcitonin (ABT403) Mouse Monoclonal Antibody
MBS9511083-1mL 1mL
EUR 580

Anti-Human Calcitonin (ABT403) Mouse Monoclonal Antibody
MBS9511083-5x1mL 5x1mL
EUR 2455

Anti-Human Calcitonin (ABT427) Mouse Monoclonal Antibody
MBS9511084-005mL 0.05mL
EUR 190

Anti-Human Calcitonin (ABT427) Mouse Monoclonal Antibody
MBS9511084-01mL 0.1mL
EUR 255

Anti-Human Calcitonin (ABT427) Mouse Monoclonal Antibody
MBS9511084-02mL 0.2mL
EUR 325

Anti-Human Calcitonin (ABT427) Mouse Monoclonal Antibody
MBS9511084-1mL 1mL
EUR 580

Anti-Human Calcitonin (ABT427) Mouse Monoclonal Antibody
MBS9511084-5x1mL 5x1mL
EUR 2455

Anti-Human Calcitonin (ABT460) Mouse Monoclonal Antibody
MBS9511085-005mL 0.05mL
EUR 190

Anti-Human Calcitonin (ABT460) Mouse Monoclonal Antibody
MBS9511085-01mL 0.1mL
EUR 255

Anti-Human Calcitonin (ABT460) Mouse Monoclonal Antibody
MBS9511085-02mL 0.2mL
EUR 325

Anti-Human Calcitonin (ABT460) Mouse Monoclonal Antibody
MBS9511085-1mL 1mL
EUR 580

Anti-Human Calcitonin (ABT460) Mouse Monoclonal Antibody
MBS9511085-5x1mL 5x1mL
EUR 2455

Anti-Human Calcitonin (ABT464) Mouse Monoclonal Antibody
MBS9511086-005mL 0.05mL
EUR 190

Anti-Human Calcitonin (ABT464) Mouse Monoclonal Antibody
MBS9511086-01mL 0.1mL
EUR 255

Anti-Human Calcitonin (ABT464) Mouse Monoclonal Antibody
MBS9511086-02mL 0.2mL
EUR 325

Anti-Human Calcitonin (ABT464) Mouse Monoclonal Antibody
MBS9511086-1mL 1mL
EUR 580

Anti-Human Calcitonin (ABT464) Mouse Monoclonal Antibody
MBS9511086-5x1mL 5x1mL
EUR 2455

Anti-Human Calcitonin (ABT481) Mouse Monoclonal Antibody
MBS9511087-005mL 0.05mL
EUR 190

Anti-Human Calcitonin (ABT481) Mouse Monoclonal Antibody
MBS9511087-01mL 0.1mL
EUR 255

Anti-Human Calcitonin (ABT481) Mouse Monoclonal Antibody
MBS9511087-02mL 0.2mL
EUR 325

Anti-Human Calcitonin (ABT481) Mouse Monoclonal Antibody
MBS9511087-1mL 1mL
EUR 580

Anti-Human Calcitonin (ABT481) Mouse Monoclonal Antibody
MBS9511087-5x1mL 5x1mL
EUR 2455

Mouse Anti Rat Calcitonin Receptor Monoclonal Antibody
CABT-49691MR 0.1 mg
EUR 667.8
Description: Mouse

Calcitonin (CT) Monoclonal Antibody (Human)
4-MAA472Hu22
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Description: A Mouse monoclonal antibody against Human Calcitonin (CT)

Calcitonin Mouse Monoclonal Antibody [Clone CALCA/3310]
MBS4382315-002mgWithBSAAzideat02mgmL 0.02mg(WithBSA&Azideat0.2mg/mL)
EUR 230

Calcitonin Mouse Monoclonal Antibody [Clone CALCA/3310]
MBS4382315-01mgWithBSAAzideat02mgmL 0.1mg(WithBSA&Azideat0.2mg/mL)
EUR 405

Calcitonin Mouse Monoclonal Antibody [Clone CALCA/3310]
MBS4382315-01mgWithoutBSAAzideat1mgmL 0.1mg(WithoutBSA&Azideat1mg/mL)
EUR 405

Calcitonin Mouse Monoclonal Antibody [Clone CALCA/3310]
MBS4382315-5x01mgWithBSAAzideat02mgmL 5x0.1mg(WithBSA&Azideat0.2mg/mL)
EUR 1725

Calcitonin Mouse Monoclonal Antibody [Clone CALCA/3310]
MBS4382315-5x01mgWithoutBSAAzideat1mgmL 5x0.1mg(WithoutBSA&Azideat1mg/mL)
EUR 1725

Mouse Anti Human Calcitonin Receptor Monoclonal Antibody
CABT-48598MH 0.1 mg
EUR 567
Description: Mouse

Mouse Anti Human Calcitonin Receptor Monoclonal Antibody
CABT-48599MH 0.1 mg
EUR 567
Description: Mouse

Mouse Monoclonal Calcitonin antibody (Biotin)
MBS5305334-05mg 0.5mg
EUR 595

Mouse Monoclonal Calcitonin antibody (Biotin)
MBS5305334-5x05mg 5x0.5mg
EUR 2525

Calcitonin (Calcitonin (CALCA)) mouse monoclonal antibody, clone OTI2F5 (formerly 2F5)
TA190005 100 µl Ask for price

Calcitonin (CT) Monoclonal Antibody (Rat), PE
4-MAA472Ra21-PE
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Description: A Mouse monoclonal antibody against Rat Calcitonin (CT). This antibody is labeled with PE.

Calcitonin (CT) Monoclonal Antibody (Rat), APC
4-MAA472Ra21-APC
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Description: A Mouse monoclonal antibody against Rat Calcitonin (CT). This antibody is labeled with APC.

Calcitonin (CT) Monoclonal Antibody (Rat), Cy3
4-MAA472Ra21-Cy3
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Description: A Mouse monoclonal antibody against Rat Calcitonin (CT). This antibody is labeled with Cy3.

Calcitonin (CT) Monoclonal Antibody (Rat), HRP
4-MAA472Ra21-HRP
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Description: A Mouse monoclonal antibody against Rat Calcitonin (CT). This antibody is labeled with HRP.

Calcitonin (CT) Monoclonal Antibody (Human), PE
4-MAA472Hu22-PE
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  • 20ul
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Description: A Mouse monoclonal antibody against Human Calcitonin (CT). This antibody is labeled with PE.

Calcitonin (CT) Monoclonal Antibody (Rat), FITC
4-MAA472Ra21-FITC
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  • 20ul
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Description: A Mouse monoclonal antibody against Rat Calcitonin (CT). This antibody is labeled with FITC.

Calcitonin (CT) Monoclonal Antibody (Human), APC
4-MAA472Hu22-APC
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  • 20ul
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Description: A Mouse monoclonal antibody against Human Calcitonin (CT). This antibody is labeled with APC.

Calcitonin (CT) Monoclonal Antibody (Human), Cy3
4-MAA472Hu22-Cy3
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  • 20ul
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Description: A Mouse monoclonal antibody against Human Calcitonin (CT). This antibody is labeled with Cy3.

Calcitonin (CT) Monoclonal Antibody (Human), HRP
4-MAA472Hu22-HRP
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  • 20ul
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Description: A Mouse monoclonal antibody against Human Calcitonin (CT). This antibody is labeled with HRP.

Calcitonin (CT) Monoclonal Antibody (Human), FITC
4-MAA472Hu22-FITC
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Description: A Mouse monoclonal antibody against Human Calcitonin (CT). This antibody is labeled with FITC.

Calcitonin (CALCA) mouse monoclonal antibody, clone 42
4PC47-42 1 mg Ask for price

Mouse Anti-Human Calcitonin monoclonal antibody, clone JID632
CABT-L2980 100 µl, 500 µl Ask for price
Description: Mouse

Mouse Anti-Human Calcitonin monoclonal antibody, clone JID632
CABT-L2980-100uL500uL 100 uL, 500 uL
EUR 602.4

Monoclonal mouse anti-human calcitonin
MBS660034-10mg 10mg
EUR 4640

Monoclonal mouse anti-human calcitonin
MBS660034-15mg 15mg
EUR 6535

Monoclonal mouse anti-human calcitonin
MBS660034-1mg 1mg
EUR 655

Monoclonal mouse anti-human calcitonin
MBS660034-25mg 25mg
EUR 10285

Monoclonal mouse anti-human calcitonin
MBS660034-5mg 5mg
EUR 2505

Calcitonin (CALCA) mouse monoclonal antibody, clone 13B9
4C10-13B9 1 mg Ask for price

Calcitonin (CALCA) mouse monoclonal antibody, clone 13F2
4C10-13F2 1 mg Ask for price

Calcitonin (CALCA) mouse monoclonal antibody, clone 14A2
4C10-14A2 1 mg Ask for price

Calcitonin (CALCA) mouse monoclonal antibody, clone 16B5
4C10-16B5 1 mg Ask for price

Calcitonin (CALCA) mouse monoclonal antibody, clone 24B2
4C10-24B2 1 mg Ask for price

Calcitonin (CALCA) mouse monoclonal antibody, clone 18B7
4PC47-18B7 1 mg Ask for price

Calcitonin (CALCA) mouse monoclonal antibody, clone 27A3
4PC47-27A3 1 mg Ask for price

Calcitonin (CALCA) mouse monoclonal antibody, clone 44D9
4PC47-44D9 1 mg Ask for price

Calcitonin (CALCA) mouse monoclonal antibody, clone 6F10
4PC47-6F10 1 mg Ask for price

Calcitonin (CALCA) mouse monoclonal antibody, clone 13G11
4C10-13G11 1 mg Ask for price

Calcitonin (CALCA) mouse monoclonal antibody, clone 14C12
4PC47-14C12 1 mg Ask for price

Calcitonin (CALCA) mouse monoclonal antibody, clone 22A11
4PC47-22A11 1 mg Ask for price

Calcitonin (CALCA) mouse monoclonal antibody, clone 38F11
4PC47-38F11 1 mg Ask for price

monoclonal anti-Human Calcitonin (CT) IgG
CT12-M 100 ug
EUR 578.4

Calcitonin (CT) Monoclonal Antibody (Rat), APC-Cy7
4-MAA472Ra21-APC-Cy7
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Description: A Mouse monoclonal antibody against Rat Calcitonin (CT). This antibody is labeled with APC-Cy7.

Calcitonin (CT) Monoclonal Antibody (Rat), Biotinylated
4-MAA472Ra21-Biotin
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Description: A Mouse monoclonal antibody against Rat Calcitonin (CT). This antibody is labeled with Biotin.

Mouse Anti Rat Calcitonin Receptor (C1b Isoform) Monoclonal Antibody
CABT-49689MR 0.1 mg
EUR 667.8
Description: Mouse

Calcitonin monoclonal antibody
MB66763 50ul
EUR 275
Description: Mouse IgM. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.
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